gp96 Leads the Way for Toll-like Receptors

The Role of Toll-Like Receptors in Breast Cancer

Breast cancer is highly prevalent worldwide. Treatment of this disease is a major global public health problem; therefore, numerous studies have explored new molecular profile helping for breast cancer therapy. Different risk factors are attributed to breast cancer; however, chronic inflammation and immune regulation are highly essential. Various molecules impact this context, including toll-li...

The Role of Toll Like Receptors in Pregnancy

Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of cochaperones. Here, we demonstrate that gp96 chaperones multiple Toll-like receptors (TLRs), but not TLR3, in a manner that is dependent on another ER luminal protein, CNPY3. gp96 directl...

I-23: Reproduction and Toll Like Receptors(TLRs

Female and male reproductive tracts are of interest sites to study of immune system because they encounter specific infections such as those are sexually transmitted. Furthermore, female reproductive tract is in close contact with allogenic sperms and transmitted microorganisms during intercourse and semi allogenic fetus during pregnancy. In mammals, there are two types of immune responses, the...